ABSTRACT
<p><b>OBJECTIVE</b>to evaluate the diagnostic accuracy of ultrasound-guided core needle biopsy of breast tumors.</p><p><b>METHODS</b>six hundred and sixty-seven cases of core needle biopsy of breast encountered during the period from January, 2004 to June, 2007 were retrieved from the archival file and retrospectively reviewed. The core needle biopsy diagnoses were correlated with the histologic findings of the subsequent surgical excision specimens. The discrepancies were further analyzed.</p><p><b>RESULTS</b>three hundred and eighty-two patients had core needle biopsy diagnosis followed by local excision, breast conservation surgery or mastectomy. Two hundred and eighty-one cases were confirmed to have malignancy in the surgical specimens. Review of the corresponding core needle biopsies showed 4 false-negative cases, no false-positive cases, 28 cases with underestimation and 2 cases with overestimation. The false-negative rate was 1.4% (4/281). The rate of underestimation for ductal carcinoma-in-situ was 6/11. The diagnostic accuracy of core needle biopsy was 94.7% (266/281).</p><p><b>CONCLUSION</b>in order to improve the diagnostic accuracy of core needle biopsy of breast tumors, recognition of the limitation of the procedure, application of immunohistochemistry and awareness of potentially rare entities are important.</p>
Subject(s)
Female , Humans , Adenocarcinoma, Mucinous , Diagnostic Imaging , Metabolism , Pathology , General Surgery , Biopsy, Needle , Methods , Breast Neoplasms , Diagnostic Imaging , Metabolism , Pathology , General Surgery , CD56 Antigen , Metabolism , Carcinoma, Ductal, Breast , Diagnostic Imaging , Metabolism , Pathology , General Surgery , Carcinoma, Intraductal, Noninfiltrating , Diagnostic Imaging , Metabolism , Pathology , General Surgery , False Negative Reactions , Keratin-5 , Metabolism , Mastectomy , Methods , Membrane Proteins , Metabolism , Retrospective Studies , Ultrasonography, Interventional , Methods , Ultrasonography, MammaryABSTRACT
Background and purpose:Neoadjuvant chemotherapy is one of the hot studied area in breast cancer research.Our aim was to explore the relationship between the clinical effect,pathological changes and the neoadjuvant chemotherapy containing THP and docetaxel on breast cancer.Methods:The expression of ER, PR and CerbB-2 in breast cancer tissue of patients who had received neoadjuvant chemotherapy were detected by immunohistochemistry method.The relationship of age,ER,PR,CerbB-2,pathological stage and axillary lymph node metastasis with pathological complete response(pCR) was analysed.Results:For the patients after neoadjuvant chemotherapy,the pCR of the positive ER(0%),PR(9.38%) was lower than that of negative ER(20.27),PR(90.63%) respectively.The pCR of the positive CerbB-2(33.33%) was higher than that of negative CerbB-2(9.74%,P